The history of Universidade Presbiteriana Mackenzie (UPM), dates back to the 19th century, when Presbyterian missionaries and educators founded it in the city of São Paulo. In 1896 the School of Engineering was opened, giving rise to Mackenzie College, which soon began to offer various courses. In 1952, with a tradition of six decades of higher education, the Brazilian government elevated the institution to the status of university. The UPM seeks to encourage innovation and entrepreneurship throughout its academic community, through institutional policies that result in actions and programs developed in its undergraduate and postgraduate courses, by the Technological Innovation Center, and for its various advanced research groups. Among these researches, those developed by the Mackenzie Radio Astronomy and Astrophysics Center (CRAAM) deserve to be highlighted, which maintains partnerships with other prominent research institutions, such as the National Institute for Space Research (Inpe) and leads the Brazilian Space Geodesy Program, in agreement with NASA (USA), through which it is responsible for an observatory in Euzébio, Ceará, where it maintains the most accurate atomic clock in the country; the Autism Spectrum Disorder Clinic, which investigates and cares for people with this disorder; the Digital TV Laboratory, which played a prominent role in the development of the Brazilian Digital TV standard; the Cognitive and Social Neuroscience Laboratory, which develops non-invasive brain mapping research, working in partnership with international research institutions, such as the Laboratory of Neuromodulation, at Harvard Medical School. The Center for Advanced Research in Graphene, Nanomaterials and Nanotechnology (MackGraphe), with the support of the São Paulo State Research Support Foundation (Fapesp), places UPM at the global forefront in this field of research and will have a strong impact on the industry technology in the next years.